RegulonDB RegulonDB 11.2: Gene Form
   

uhpT gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

adeD uhpT uhpC uhpU CRP UhpA UhpA uhpTp uhpTp

Gene      
Name: uhpT    Texpresso search in the literature
Synonym(s): ECK3657, EG11054, b3666
Genome position(nucleotides): 3845776 <-- 3847167
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 52.87
External database links:  
ASAP:
 ABE-0011981
CGSC:
 37
ECHOBASE:
 EB1047
ECOLIHUB:
 uhpT
OU-MICROARRAY:
 b3666
STRING:
 511145.b3666
COLOMBOS: uhpT


Product      
Name: hexose-6-phosphate:phosphate antiporter
Synonym(s): UhpT, UhpT-hexose phosphate MFS transporter
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 50.607
Isoelectric point: 8.99
Motif(s):
 
Type Positions Sequence Comment
25 -> 45 FKPFMQSYLVVFIGYLTMYLI UniProt: Helical.
35 -> 397 VFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGSGSVSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLGKAEELFGEEISEEDKETESTDMTKWQIFVEYVLKNKVIWLLCFANIFLYVVRIGIDQWSTVYAFQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSDLANGRRGLVACIALALIIATLGVYQHASNEYIYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYL
61 -> 81 GLSMTQLGMIGLGFSITYGVG UniProt: Helical.
97 -> 117 FLPFMLILSAICMLGFSASMG UniProt: Helical.
108 -> 108 C UniProt: No change in activity..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0061513 - glucose 6-phosphate:inorganic phosphate antiporter activity
GO:0022857 - transmembrane transporter activity
GO:0015526 - hexose-phosphate:inorganic phosphate antiporter activity
biological_process GO:0008643 - carbohydrate transport
GO:0006817 - phosphate ion transport
GO:0055085 - transmembrane transport
GO:0015712 - hexose phosphate transport
GO:0015760 - glucose-6-phosphate transport
GO:0035435 - phosphate ion transmembrane transport
Note(s): Note(s): ...[more].
Reference(s): [1] Dietz GW. 1978
[2] Dietz GW., et al., 1971
[3] Fann MC., et al., 1998
[4] Pogell BM., et al., 1966
[5] Sonna LA., et al., 1988
[6] Weston LA., et al., 1987
[7] Winkler HH. 1970
External database links:  
ALPHAFOLD:
 P0AGC0
ECOCYC:
 UHPT-MONOMER
ECOLIWIKI:
 b3666
INTERPRO:
 IPR021159
INTERPRO:
 IPR020846
INTERPRO:
 IPR011701
INTERPRO:
 IPR000849
INTERPRO:
 IPR036259
MODBASE:
 P0AGC0
PFAM:
 PF07690
PRIDE:
 P0AGC0
PRODB:
 PRO_000024171
PROSITE:
 PS00942
PROSITE:
 PS50850
REFSEQ:
 NP_418122
UNIPROT:
 P0AGC0


Operon      
Name: uhpT         
Operon arrangement:
Transcription unit        Promoter
uhpT


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, UvrY, UhpA


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Dietz GW., 1978, Growth of Escherichia coli on glucosamine 6-phosphate: selection of a constitutive hexose phosphate transport system mutant., Can J Microbiol 24(3):203-8

 [2] Dietz GW., Heppel LA., 1971, Studies on the uptake of hexose phosphates. II. The induction of the glucose 6-phosphate transport system by exogenous but not by endogenously formed glucose 6-phosphate., J Biol Chem 246(9):2885-90

 [3] Fann MC., Maloney PC., 1998, Functional symmetry of UhpT, the sugar phosphate transporter of Escherichia coli., J Biol Chem 273(50):33735-40

 [4] Pogell BM., Maity BR., Frumkin S., Shapiro S., 1966, Induction of an active transport system for glucose 6-phosphate in Escherichia coli., Arch Biochem Biophys 116(1):406-15

 [5] Sonna LA., Ambudkar SV., Maloney PC., 1988, The mechanism of glucose 6-phosphate transport by Escherichia coli., J Biol Chem 263(14):6625-30

 [6] Weston LA., Kadner RJ., 1987, Identification of uhp polypeptides and evidence for their role in exogenous induction of the sugar phosphate transport system of Escherichia coli K-12., J Bacteriol 169(8):3546-55

 [7] Winkler HH., 1970, Compartmentation in the induction of the hexose-6-phosphate transport system of Escherichia coli., J Bacteriol 101(2):470-5

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