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AlsR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
RpiB AlsC aldehydo-D-allose-6-P allose_Ext AlsA AlsB AlsE rpiB AlsR alsRBACE AlsA ribose-5P allose allulose-6-P rpiB_mRNA AlsC allose fructose-6-P AlsB AlsR ribulose-5P alsRBACE_mRNA


Gensor Unit       
Name: AlsR
Description: Molecular biology level
Detailed: In the absence of D-allose, AlsR negatively regulates the expression of genes required for D-allose importing and catabolic process. Under this condition, AlsR binds its target sites preventing its own expression and the expression of its regulated genes. In the presence of D-allose, AlsR is modified to AlsR-D-allose, unbinds its target sites enabling its own expression and the expression of its regulated genes.
Less detailed: In the absence of D-allose, AlsR negatively regulates the expression of genes needed for D-allose importing and catabolic process.

Physiology level
Detailed: The presence of D-allose induces the expression of genes involved with D-allose uptake and assimilation. Under this condition the genes necessary for D-allose uptake and degradation to D-fructuose-6-phosphate (a substrate for glycolysis), are expressed.
Less detailed: The presence of D-allose induces the expression of genes needful for D-allose uptake and degradation to D-fructuose-6-phosphate (which feeds the glycolysis).
Classification:
Groups: Transcription
Carbohydrate transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0019316 - D-allose catabolic process
GO:0015754 - allose transmembrane transport
GO:1901135 - carbohydrate derivative metabolic process
GO:0005975 - carbohydrate metabolic process
GO:0008643 - carbohydrate transport
GO:0044262 - cellular carbohydrate metabolic process
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cellular_component GO:0043190 - ATP-binding cassette (ABC) transporter complex
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0042597 - periplasmic space
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molecular_function GO:0015407 - ABC-type monosaccharide transporter activity
GO:0005524 - ATP binding
GO:0016887 - ATP hydrolysis activity
GO:0004750 - D-ribulose-phosphate 3-epimerase activity
GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0008786 - allose 6-phosphate isomerase activity
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Components:
  Function Name Type
  protein AlsA protein
  complex AlsA-AlsC-AlsB complex
  protein AlsB protein
  protein AlsC protein
  protein AlsE protein
  protein AlsR protein
  complex AlsR-allose complex
  protein RpiB protein
  simple_molecule aldehydo-D-allose-6-P simple_molecule
  simple_molecule allose simple_molecule
  simple_molecule allose_Ext simple_molecule
  simple_molecule allulose-6-P simple_molecule
  gene alsRBACE gene
  RNA alsRBACE_mRNA RNA
  simple_molecule fructose-6-P simple_molecule
  simple_molecule ribose-5P simple_molecule
  simple_molecule ribulose-5P simple_molecule
  gene rpiB gene
  RNA rpiB_mRNA RNA


Reactions       
Showing 14 reactions
AlsR alsRBACE alsRBACE_mRNA
Name: alsRBACE -> alsRBACE_mRNA
Description: Transcription of transcription unit alsRBACE. Reaction inhibition by AlsR.
Type: transcription
Pathway Components: alsRBACE - AlsR -> alsRBACE_mRNA
Components:
Function Name Type
inhibitor AlsR protein
reactant alsRBACE gene
product alsRBACE_mRNA RNA
AlsR rpiB rpiB_mRNA
Name: rpiB -> rpiB_mRNA
Description: Transcription of transcription unit rpiB. Reaction inhibition by AlsR.
Type: transcription
Pathway Components: rpiB - AlsR -> rpiB_mRNA
Components:
Function Name Type
inhibitor AlsR protein
reactant rpiB gene
product rpiB_mRNA RNA
allose + AlsR AlsR-allose
Name: allose + AlsR -> AlsR-allose
Description: Reaction transforming allose, AlsR into AlsR-allose
Type: state transition
Pathway Components: allose + AlsR -> AlsR-allose
Components:
Function Name Type
reactant AlsR protein
product AlsR-allose complex
reactant allose simple_molecule
alsRBACE_mRNA AlsR
Name: alsRBACE_mRNA -> AlsR
Description: Translation of AlsR
Type: translation
Pathway Components: alsRBACE_mRNA -> AlsR
Components:
Function Name Type
product AlsR protein
reactant alsRBACE_mRNA RNA
alsRBACE_mRNA AlsB
Name: alsRBACE_mRNA -> AlsB
Description: Translation of AlsB
Type: translation
Pathway Components: alsRBACE_mRNA -> AlsB
Components:
Function Name Type
product AlsB protein
reactant alsRBACE_mRNA RNA
AlsB + AlsA + AlsC AlsA-AlsC-AlsB
Name: AlsB + AlsA + AlsC -> AlsA-AlsC-AlsB
Description: Reaction transforming AlsB, AlsA, AlsC into AlsA-AlsC-AlsB
Type: state transition
Pathway Components: AlsB + AlsA + AlsC -> AlsA-AlsC-AlsB
Components:
Function Name Type
reactant AlsA protein
product AlsA-AlsC-AlsB complex
reactant AlsB protein
reactant AlsC protein
AlsA-AlsC-AlsB allose_Ext allose
Name: allose_Ext -> allose
Description: Transport of allose_Ext through a bacterial membrane, leading to the presence of allose inside the cell.
Type: transport
Pathway Components: allose_Ext - AlsA-AlsC-AlsB -> allose
Components:
Function Name Type
catalyzer AlsA-AlsC-AlsB complex
product allose simple_molecule
reactant allose_Ext simple_molecule
alsRBACE_mRNA AlsA
Name: alsRBACE_mRNA -> AlsA
Description: Translation of AlsA
Type: translation
Pathway Components: alsRBACE_mRNA -> AlsA
Components:
Function Name Type
product AlsA protein
reactant alsRBACE_mRNA RNA
alsRBACE_mRNA AlsC
Name: alsRBACE_mRNA -> AlsC
Description: Translation of AlsC
Type: translation
Pathway Components: alsRBACE_mRNA -> AlsC
Components:
Function Name Type
product AlsC protein
reactant alsRBACE_mRNA RNA
alsRBACE_mRNA AlsE
Name: alsRBACE_mRNA -> AlsE
Description: Translation of AlsE
Type: translation
Pathway Components: alsRBACE_mRNA -> AlsE
Components:
Function Name Type
product AlsE protein
reactant alsRBACE_mRNA RNA
AlsE allulose-6-P fructose-6-P
Name: allulose-6-P -> fructose-6-P
Description: Reaction transforming allulose-6-P into fructose-6-P
Type: state transition
Pathway Components: allulose-6-P - AlsE -> fructose-6-P
Components:
Function Name Type
catalyzer AlsE protein
reactant allulose-6-P simple_molecule
product fructose-6-P simple_molecule
rpiB_mRNA RpiB
Name: rpiB_mRNA -> RpiB
Description: Translation of RpiB
Type: translation
Pathway Components: rpiB_mRNA -> RpiB
Components:
Function Name Type
product RpiB protein
reactant rpiB_mRNA RNA
RpiB aldehydo-D-allose-6-P allulose-6-P
Name: aldehydo-D-allose-6-P -> allulose-6-P
Description: Reaction transforming aldehydo-D-allose-6-P into allulose-6-P
Type: state transition
Pathway Components: aldehydo-D-allose-6-P - RpiB -> allulose-6-P
Components:
Function Name Type
catalyzer RpiB protein
reactant aldehydo-D-allose-6-P simple_molecule
product allulose-6-P simple_molecule
RpiB ribose-5P ribulose-5P
Name: ribose-5P -> ribulose-5P
Description: Reaction transforming ribose-5P into ribulose-5P
Type: state transition
Pathway Components: ribose-5P - RpiB -> ribulose-5P
Components:
Function Name Type
catalyzer RpiB protein
reactant ribose-5P simple_molecule
product ribulose-5P simple_molecule
R1 R2 R3 R4 R5 R6 R7 R8 R9 R10 R11 R12 R13 R14



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