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| Synonyms: HdfR |
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Summary:
"Hns-dependent flhDCregulator," HdfR, negatively regulates the expression of the flagellar master operon, flhDC [1]and positively regulates the expression of the gltBD operon [2] H-NS is a direct activator of the flhDC operon and represses transcription of hdfR. HdfR is a transcriptional regulator that belongs to the LysR family. It consist of two domains, an amino-terminal domain that contains a potential helix-turn-helix DNA-binding motif and a carboxy-terminal domain involved in co-inducer recognition [1, 4] Little is known about the regulatory role of HdfR, and the binding sites for this transcription factor have not yet been determined. In systematic studies of oligomerization, it was shown that some members of the LysR family, like HdfR, interact with other members of the family to form heterodimers, but the physiological significance of this is unknown [5] The hdfR gene loss of function caused by an amino acid change of glutamate to lysine favored NADPH availability in E. Read more > |
| Transcription factor |  |
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| TF conformation(s): |
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| Evolutionary Family: | LysR | ||||||||||||||
| TFBs symmetry: | inverted-repeat | ||||||||||||||
| Connectivity class: | Local Regulator | ||||||||||||||
| Gene name: | hdfR | ||||||||||||||
| Genome position: | 3947128-3947967 | ||||||||||||||
| Length: | 840 bp / 279 aa | ||||||||||||||
| Operon name: | hdfR | ||||||||||||||
| TU(s) encoding the TF: |
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| Regulon |
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| Regulated gene(s) | flhC, flhD, gltB, gltD, gltF | ||||||
| Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
operon (3)
flagellum (2)
Transcription related (2)
activator (2)
repressor (2)
Read more >
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| Regulated operon(s) | flhDC, gltBDF | ||||||
| First gene in the operon(s) | flhD, gltB | ||||||
| Simple and complex regulons | AcrR,CRP,FliZ,Fur,H-NS,HdfR,IHF,LrhA,MatA,OmpR,QseB,RcsAB,YjjQ AdiY,ArgR,CRP,FNR,Fur,GadE,HdfR,IHF,Lrp,Nac | ||||||
| Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) | ||||||
| Transcription factor regulation |
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Transcription factor binding sites (TFBSs) arrangements
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| Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence | Confidence level (C: Confirmed, S: Strong, W: Weak) | References | |
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| HdfR | repressor | flhDp | Sigma70 | nd | nd | flhD, flhC | nd | nd | [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] | S | [1], [1] | ||
| HdfR | activator | gltBp | Sigma70 | nd | nd | gltB, gltD, gltF | nd | nd | [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] | S | [2], [2] | ||
| HdfR | activator | gltBp2 | Sigma38 | nd | nd | gltB, gltD, gltF | nd | nd | [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] | S | [2], [2] |
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High-throughput Transcription factor binding sites (TFBSs)
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| Functional conformation | Function | Object name | Object type | Distance to first Gene | Sequence | LeftPos | RightPos | Center Position | Growth Condition | Evidence | Confidence level (C: Confirmed, S: Strong, W: Weak) | References | |
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| HdfR | activator | yifE | Transcription-Unit | nd | nd | nd | nd | nd | [EXP-IEP-GENE-EXPRESSION-ANALYSIS] | W | [3] |
| Evolutionary conservation of regulatory elements | |
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| Promoter-target gene evolutionary conservation |
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| Reference(s) |
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[EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis