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| Synonyms: MatA |
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Summary:
MatA is a LuxR-type transcription factor that is directly involved, as a positive regulator acting at transcriptional and posttranscriptional levels, in the expression of the mat operon in meningitis isolate strain IHE 3034 (T. A. Lehti, P. Bauchart, M. Kukkonen, U. Dobrindt, T. K. Korhonen, B. Westerlund-Wikström, unpublished results) [1]. On the other hand, MatA controls the expression of the flhDC operon, with higher affinity to flhDp, repressing flagellum biosynthesis, motility, and taxis [1]. The opposite regulatory actions of MatA on mat and on flhDC promoters advance the adaptation of E. coli from a planktonic to an adhesive lifestyle [1]. MatA binds more weakly to pfliA and to pfliC, and their levels are equal to those observed for matB [1]. MatA exerts a dual regulatory function on the choice of planktonic/sessile lifestyle and further supports the presence of antagonistic control of attachment and motility. Read more > |
| Transcription factor |  |
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| TF conformation(s): |
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| Evolutionary Family: | LuxR/UhpA | ||||||||||||||
| TFBs symmetry: | inverted-repeat | ||||||||||||||
| Connectivity class: | Local Regulator | ||||||||||||||
| Gene name: | matA | ||||||||||||||
| Genome position: | 310746-311336 | ||||||||||||||
| Length: | 591 bp / 196 aa | ||||||||||||||
| Operon name: | matA | ||||||||||||||
| TU(s) encoding the TF: |
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| Regulon |
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| Regulated gene(s) | ecpA, flhC, flhD, fliA, fliC, fliX, fliZ, matA, tcyJ | ||||||
| Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
motility, chemotaxis, energytaxis (aerotaxis, redoxtaxis etc) (4)
flagella (4)
flagellum (3)
Transcription related (3)
activator (2)
Read more >
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| Regulated operon(s) | ecpA, flhDC, fliAZ-tcyJ, fliCX, matA | ||||||
| First gene in the operon(s) | ecpA, matA, flhD, fliA, fliC | ||||||
| Simple and complex regulons | AcrR,CRP,FliZ,Fur,H-NS,HdfR,IHF,LrhA,MatA,OmpR,QseB,RcsAB,YjjQ CsgD,FlhDC,H-NS,IHF,MatA,NsrR,SutR GadE,H-NS,MatA MatA | ||||||
| Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) | ||||||
| Transcription factor regulation |
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Transcription factor binding sites (TFBSs) arrangements
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| Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence | Confidence level (C: Confirmed, S: Strong, W: Weak) | References | |
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| MatA | activator | ecpAp | Sigma70 | nd | nd | ecpA | nd | nd | [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] | S | [1], [1] | ||
| MatA | activator | ecpRp | Sigma24 | nd | nd | matA | nd | nd | [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] | S | [1], [1] | ||
| MatA | repressor | flhDp | Sigma70 | nd | nd | flhD, flhC | nd | nd | [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] | S | [1], [1] | ||
| MatA | repressor | flhDp2 | Sigma54 | nd | nd | flhD, flhC | nd | nd | [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] | S | [1], [1] | ||
| MatA | repressor | fliAp1 | Sigma70 | nd | nd | fliA, fliZ, tcyJ | nd | nd | [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] | S | [1], [1] | ||
| MatA | repressor | fliCp | Sigma28 | nd | nd | fliC, fliX | nd | nd | [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] | S | [1], [1] |
| Evolutionary conservation of regulatory elements | |
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| Promoter-target gene evolutionary conservation |
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[EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] Binding of purified proteins